Pleiotropic Effects of HMG-CoA Reductase Inhibitors - KI Open


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In pharmacology, pleiotropy includes all of a drug's actions other than those for which the agent was specifically developed. It may include adverse effects which are detrimental ones, but is often used to denote additional beneficial effects. The Pleiotropic Effects of the Canonical Wnt Pathway in Early Development and Pluripotency. de Jaime-Soguero A(1), Abreu de Oliveira WA(2), Lluis F(3).

Pleiotropic effects

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This retrospective cohort study included patients with dyslipidemia who had been newly treated with statin or fibrate monotherapy between January 2005 and December 2017. Patients were randomly matched into two sets of pairs by sex, age, and baseline triglyceride (TG) or low The pleiotropic effect is produced by a gene owing to a cascade (succession) of reactions during some metabolic pathway which is influenced by the original gene product and contributes to different phenotypic effects. The ratio is 2:1 instead of 3:1. 2021-01-04 Most of the effects of statins can be explained by pleiotropic effects independent of their lowering of serum cholesterol; in some cases, these effects have been shown to be a result of the role However, the lipid-lowering effect is not the only effect of action described by researchers that PCSK-9 inhibitors have. This paper is a review of the literature describing the pleiotropic effects of PCSK-9 inhibitors, which belong to a group of drugs that are being increasingly used, especially when standard lipid-lowering therapy fails. MECHANISM OF ACTION, AND PLEIOTROPIC EFFECTS Sylvia Christakos, Puneet Dhawan, Annemieke Verstuyf, Lieve Verlinden, and Geert Carmeliet Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey; and Laboratory of Clinical and Experimental Pleiotropy occurs when one gene influences two or more seemingly unrelated phenotypic traits. Such a gene that exhibits multiple phenotypic expression is called a pleiotropic gene.

Thus, a new mutation in the gene will affect all the phenotypes/traits  28 maj 2013 — In this study, three pig lines were used for the estimation of pleiotropic effect of the 1.94 Mbp region on SSC6: sow line 1 (~1450 animals); sow  Pleiotropic Effects of GIP on Islet Function Involve Osteopontin.

[PDF] Characterization of Pleiotropic Activities of alpha1

The genetically predicted effect of statin use on IHD in specifically men was partially  Jun 25, 2008 Keywords: Pleiotropic effectsStatinsLow-density lipoprotein Ongoing interest in the pleiotropic effects of statins has extended to their  Abstract Under field conditions in Germany over three growing seasons the pleiotropic effects on yield and its components of four sets of near isogenic lines  Conclusions: These data suggest that the anti-atherosclerotic pleiotropic effect of cilostazol resulted in the reduction of spontaneous infarct volume in SHR-SP  Omega-3 fatty acids except for their effect on triglycerides levels have cardioprotective properties as well as antiarrhythmic properties.The pleiotropic effects of  Jan 10, 2014 Pleiotropic effects of statins in atherosclerotic disease composition can be ascribed to LDL lowering or an anti-inflammatory pleiotropic effect. Feb 26, 2015 The benefit of statins in the prevention of cardiovascular disease is well founded, derived from their lipid lowering and pleiotropic effects.

Pleiotropic effects

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Pleiotropic effects

pleiotropy [pli-ot´rŏ-pe] the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen. Miller-Keane Encyclopedia 2007-06-01 2020-09-01 2015-12-17 Many of these pleiotropic effects are mediated by inhibition of isoprenoids, which serve as lipid attachments for intracellular signaling molecules.

Today we are going to be discussing how different traits can be expressed, and the way in which a trait is expressed can have an effect on a person's genotype or  Oct 17, 2008 Statin administration has been associated with the depletion of peripheral blood monocytes, which play a pivotal role in immune response. Pleiotropic gene has a multiple phenotypic effect because it can control expression of a number of characters.
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How to use pleiotropic in a sentence. Nov 19, 2018 Statins exerts their pleiotropic effects by hindering the conversion of HMG-CoA to L-mevalonic corrosive, statins keep the union of imperative  Aug 25, 2020 Multivariable Mendelian randomization estimates for effects of genetically mimicked statins (effect sizes of LDL-cholesterol) and of testosterone (  Jan 28, 2021 We also evaluated the effect of short-term GOS feeding on how the aging gut microbiome responds to antibiotic challenges, since these  Official Title: A Multicenter, Randomized Double-Blind Study Comparing The Pleiotropic Effects Of Atorvastatin 10 Mg And 80 Mg Over A 26-Week Period In  May 1, 2019 Pleiotropic genes are genes that affect more than one trait. For example, many genes required for pigmentation in the fruit fly Drosophila  Nov 5, 2015 Selected genes may be pleiotropic, affecting multiple phenotypes and resulting in more than one disease or trait.

1,2 They include increases in endothelial nitric oxide formation; flow-mediated vascular dilatation; suppression of vascular inflammation; reduction of circulating biomarkers that indicate inflammation (such as C-reactive protein); a reduction in T-cell activation with a decrease in cytokines; promotion of neovascularization in ischemic tissue; and modulation of thrombosis and coagulation. Statins may exert cardiovascular protective effects that are independent of LDL-cholesterol lowering called pleiotropic effects.
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The curling of the feathers leads to a loss of body heat requiring a faster basal metabolism to maintain homeostasis.